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February 2020 — Cytopathology, Clinical Microbiology, Gastroenterology & Infectious Disease

A 65-year-old man with history of treated anal intraepithelial neoplasia presents with new-onset diarrhea. A Papanicolaou-stained anal smear was performed for follow-up cancer screening.

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Photo of Nicholas Boire, M.D., M.Sc. Nicholas Boire, M.D., M.S.
Resident, Anatomic and Clinical Pathology
Mayo Clinic
@DrBoire
Image of Bobbi Pritt, M.D. Bobbi Pritt, M.D.
Consultant, Clinical Microbiology
Mayo Clinic
Professor of Laboratory Medicine and Pathology
Mayo Clinic College of Medicine and Science
@ParasiteGal
Photo of Charles D. Sturgis, M.D. Charles Sturgis, M.D.
Senior Associate Consultant, Anatomic Pathology
Mayo Clinic

February 2020 — Anatomic Pathology

78 year old man with new onset bilateral shoulder/neck pain and weakness, jaw pain exacerbated by chewing, and odynophagia with both solids and liquids. A vascular biopsy was performed (see virtual slide).

CLICK IMAGE TO SEE: Virtual Microscopy

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Photo of Alessia Buglioni, M.D.
Alessia Buglioni, M.D.

Resident, Anatomic and Clinical Pathology
Mayo Clinic
Photo of John Cheville, M.D. John Cheville, M.D.
Consultant, Anatomic Pathology
Mayo Clinic
Professor of Laboratory Medicine and Pathology
Mayo Clinic College of Medicine and Science

February 2020 — Hematopathology

A 43-year-old female presents with seizures following weeks of progressive lower extremity numbness. Imaging reveals a contrast-enhancing parasagittal brain mass without other systemic findings. She underwent brain biopsy (see photomicrographs below). Additional immunohistochemical stains for CD30, ALK, and infection (toxoplasma, HSV, CMV, VZV, adenovirus) are negative. EBV in situ hybridization is negative. Clonal T-cell receptor gene rearrangement is detected by molecular analysis.

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Photo of Daniel (Dan) P. Larson, M.D.
Daniel (Dan) P. Larson, M.D.

Resident, Hematopathology
Mayo Clinic
William Macon, M.D.
Consultant, Hematopathology
Mayo Clinic
Professor of Laboratory Medicine and Pathology
Mayo Clinic College of Medicine and Science

February 2020 — Laboratory Genetics & Genomics

A 71 yr old female with a history of a central nervous system lymphoma, an allogenic stem cell transplant and graft versus host disease was tested for hereditary hemochromatosis. DNA extracted from whole blood was tested by a multiplex PCR based assay utilizing a Mass Array platform. Molecular testing showed two copies of mutated C282Y allele, two copies of wild type H63H allele and a small fraction of wild type C282C and mutated H63D (mass spectra below). Sanger sequencing confirmed these results.

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Katarzyna Thompson, Ph.D. Katarzyna Thompson, Ph.D.
Fellow, Laboratory Genetics and Genomics
Mayo Clinic
Photo of Kandelaria (Ande) Rumilla, M.D. Kandelaria (Ande) Rumilla, M.D.
Consultant, Laboratory Genetics and Genomics
Mayo Clinic
Assistant Professor of Laboratory Medicine and Pathology
Mayo Clinic College of Medicine and Science
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This post was developed by our Education and Technical Publications Team.