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March 2020 — Clinical Chemistry

A 37-year-old female diagnosed with attention-deficit hyperactive disorder (ADHD) presented for her annual Adderall (amphetamine and d-amphetamine) compliance testing visit and prescription refill.

The confirmatory amphetamine urine test results were as follows:

Drug

Result

Cut-off

Amphetamine

15,988 ng/mL

< 25 ng/mL

Methamphetamine

58 ng/mL

< 25 ng/mL

Phentermine

negative

< 25 ng/mL

MDA

negative

< 25 ng/mL

MDMA

negative

< 25 ng/mL

Pseudoephedrine/ephedrine

negative

< 25 ng/mL

This patient also had a history of polysubstance abuse (methamphetamines and cocaine); however, self-reported as being in remission for a number of years. Based on the results, the provider was concerned that the patient had relapsed and started abusing methamphetamine again.

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Photo of Sarah Delaney, Ph.D. Sarah Delaney, Ph.D.
Fellow, Clinical Chemistry
Mayo Clinic
Photo of Loralie J. Langman, Ph.D. Loralie Langman, Ph.D.
Consultant, Clinical Biochemistry
Mayo Clinic
Professor of Laboratory Medicine and Pathology
Mayo Clinic College of Medicine and Science
Image of Paul Jannetto, Ph.D. Associate Professor of Laboratory Medicine and Pathology, Division of Clinical Biochemistry, Mayo Clinic, Rochester, Minnesota Paul Jannetto, Ph.D.
Consultant, Clinical Biochemistry
Mayo Clinic
Associate Professor of Laboratory Medicine and Pathology
Mayo Clinic College of Medicine and Science
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This post was developed by our Education and Technical Publications Team.