A middle-aged man presented with multisystem manifestations, including diarrhea and abdominal pain, unintentional weight loss and hypoalbuminemia, chronic heart failure, seronegative spondyloarthropathy, and diffuse lymphadenopathy. In the past, he had been treated with secukinumab, methotrexate, and prednisone for seronegative spondyloarthropathy, without significant improvement. The following photomicrographs are from the duodenal biopsies.
|Burak Tekin, M.D.
Resident, Anatomic and Clinical Pathology
|Roger Moreira, M.D.
Consultant, Anatomic Pathology
Assistant Professor of Laboratory Medicine and Pathology
Mayo Clinic College of Medicine and Science