April 2020 — Gastroenterology

A middle-aged man presented with multisystem manifestations, including diarrhea and abdominal pain, unintentional weight loss and hypoalbuminemia, chronic heart failure, seronegative spondyloarthropathy, and diffuse lymphadenopathy. In the past, he had been treated with secukinumab, methotrexate, and prednisone for seronegative spondyloarthropathy, without significant improvement. The following photomicrographs are from the duodenal biopsies.

HE x 100
HE x 400
PAS x 200

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Burak Tekin, M.D.
Resident, Anatomic and Clinical Pathology
Mayo Clinic
Photo of Roger Moreira, M.D. Roger Moreira, M.D.
Consultant, Anatomic Pathology
Mayo Clinic
Assistant Professor of Laboratory Medicine and Pathology
Mayo Clinic College of Medicine and Science
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