April 2020 — Neuropathology

An 18-year-old man presented with progressive headaches, left face and tongue sensory change, and gait imbalance for four months. He had no significant past medical or family history. Magnetic resonance imaging (MRI) of the brain revealed a 4.7 x 4.4 x 3.9 cm right lateral ventricle mass, extending medially to compress the third ventricle and causing obstructive hydrocephalus. A gross total resection of the tumor was performed.

T1 post-contrast axial MRI demonstrates a well circumscribed, multilobulated strongly enhancing mass within the right lateral ventricle compressing the foramen of Monro (arrow).
The tumor consists of fascicles and sheets of spindled cells (A) admixed with large, ganglion-like cells with glassy cytoplasm, vesicular nuclei and prominent nucleoli (B).
Tumor cells show diffuse S100 protein (A) and TTF-1 (B) immunoexpression.
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Photo of Maria Adelita (Adelita) Vizcaino Villalobos, M.D. Maria Adelita Vizcaino Villalobos, M.D.
Resident, Anatomic Pathology/Neuropathology
Mayo Clinic
Photo of Caterina Giannini, M.D., Ph.D. Caterina Giannini, M.D., Ph.D.
Consultant, Anatomic Pathology
Mayo Clinic
Professor of Laboratory Medicine and Pathology and Neurosurgery
Mayo Clinic College of Medicine and Science

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