| Web: | mayocliniclabs.com |
|---|---|
| Email: | mcl@mayo.edu |
| Telephone: | 800-533-1710 |
| International: | +1 855-379-3115 |
| Values are valid only on day of printing | |
| Web: | mayocliniclabs.com |
|---|---|
| Email: | mcl@mayo.edu |
| Telephone: | 800-533-1710 |
| International: | +1 855-379-3115 |
| Values are valid only on day of printing | |
A 73 year old male with no underlying illness presented with watery diarrhea, bloating and intermittent abdominal pain. He was initially scheduled to have colonoscopy; however, he developed bowel perforation which required an exploratory laparotomy. A segment of the small bowel was resected.
The correct answer is...
The correct answer is Monomorphic epitheliotropic intestinal T-cell lymphoma
Monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL) is a primary intestinal T-cell lymphoma derived from the intraepithelial lymphocytes. Unlike enteropathy associated T-cell lymphoma, it is not associated with celiac disease and lacks an inflammatory background. The neoplastic cells have medium-sized nuclei with disepersed chromatin and moderate pale eosinophilic to clear cytoplasm. Epitheliotropism is usually prominent. MEITL has a distinctive phenotype with positive expression for CD3, CD8 and CD56 and is usually T-cell receptor (TCR) gamma-delta derived. MEITL prognosis is poor with a median survival of 7 months.
References
1. Swerdlow SH, Campo E, Harris NL, eds. WHO classification of tumours
of haematopoietic and lymphoid tissues. 4th ed. Lyon, France:
IARC; 2017.
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Majd Jawad, M.D. Resident, Hematopathology Mayo Clinic @MajdJawad10 |
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Adam Wood, D.O. Consultant, Hematopathology Mayo Clinic Assistant Professor of Laboratory Medicine and Pathology Mayo Clinic College of Medicine and Science |
