February 2021 — Liver Pathology

Liver explant (40x, HE & PAS-D stain), 30-year-old man with cirrhosis. 

Pathways Feb 2021 Wang 1 HE
Figure 1: A1AT HE
Pathways Feb 2021 Wang 2 A1AT PAS-D
Figure 2: A1AT PAS-D

Which gene mutation is responsible for the pathologic changes of hepatocytes?

  • ATP7B
  • HFE
  • CFTR

The correct answer is ...

The diagnosis in this case is: SERPINA1.


  1. Surgical Pathology of Liver. Michael Torbenson, Lizhi Zhang, Roger Moreire. 2018 Wolters Kluwer.
Yaohong Wang MD PhD Profile Photo Square

Yaohong Wang, B.Med, PhD

Fellow, Gastroenterology & Liver Pathology
Mayo Clinic

Zhang Lizhi, MD

Consultant, Anatomic Pathology
Mayo Clinic
Professor of Laboratory Medicine and Pathology
Mayo Clinic College of Medicine and Science

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