February 2021 — Liver Pathology

By MCL Education • February 12, 2021

Liver explant (40x, HE & PAS-D stain), 30-year-old man with cirrhosis. 

Pathways Feb 2021 Wang 1 HE
Figure 1: A1AT HE
Pathways Feb 2021 Wang 2 A1AT PAS-D
Figure 2: A1AT PAS-D

Which gene mutation is responsible for the pathologic changes of hepatocytes?

  • ATP7B
  • HFE
  • CFTR
  • SERPINA1

The correct answer is ...

The diagnosis in this case is: SERPINA1.

References

  1. Surgical Pathology of Liver. Michael Torbenson, Lizhi Zhang, Roger Moreire. 2018 Wolters Kluwer.
Yaohong Wang MD PhD Profile Photo Square

Yaohong Wang, B.Med, PhD

Fellow, Gastroenterology & Liver Pathology
Mayo Clinic

Zhang Lizhi, MD

Consultant, Anatomic Pathology
Mayo Clinic
Professor of Laboratory Medicine and Pathology
Mayo Clinic College of Medicine and Science

MCL Education

This post was developed by our Education and Technical Publications Team.

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