Mayo Clinic laboratory and pathology research roundup: June 8

By Samantha Rossi • June 8, 2021

Share this:

The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.

Featured Abstract

Heterogeneous delivery across the blood-brain barrier limits the efficacy of an EGFR-targeting antibody drug conjugate in glioblastoma. 

Antibody drug conjugates (ADCs) targeting the epidermal growth factor receptor (EGFR), such as depatuxizumab mafodotin (Depatux-M), is a promising therapeutic strategy for glioblastoma (GBM) but recent clinical trials did not demonstrate a survival benefit. Understanding the mechanisms of failure for this promising strategy is critically important. Via Neuro-Oncology

Read more.

Published to PubMed This Week

• Ceramide scores predict cardiovascular risk in the community. 
  Arteriosclerosis, Thrombotic, Vascular, and Biology
• Proton therapy for breast cancer: A consensus statement from the particle therapy cooperative group (PTCOG) breast cancer subcommittee. 
  International Journal of Radiation, Oncology, Biology, and Physics
• Lessons from the tragedy of COVID-19 and the absence of an influenza season. 
  American Journal of Medicine
• IGVL gene region usage correlates with distinct clinical presentation in IgM vs non-IgM light chain amyloidosis. 
  Blood Advances
• Clinical manifestations of, diagnostic approach to, and treatment of neurolymphomatosis in the rituximab era. 
  Blood Advances
• A new D-Galactose treatment monitoring index for PGM1-CDG. 
  Journal of Inherited Metabolic Disease
• Biomarkers of endothelial dysfunction in alcoholic hepatitis. 
  Hepatology International
• Synovial fluid α defensin has comparable accuracy to synovial fluid white blood cell count and polymorphonuclear percentage for periprosthetic joint infection diagnosis. 
  Bone and Joint Journal
• Mass spectrometric analysis of urine from COVID-19 patients for detection of SARS-CoV-2 viral antigen and to study host response. 
  Journal of Proteome Research
• Validation of a multiplex flow immunoassay for detection of IgG antibodies against SARS-CoV-2 in dried blood spots. 
  PLoS One

Samantha Rossi

Samantha Rossi is a Digital Marketing Manager at Mayo Clinic Laboratories. She supports marketing strategies for product management and specialty testing. Samantha has worked at Mayo Clinic since 2019.