Mayo Clinic Laboratory and pathology research roundup: June 14

By Meghann Southwick • June 14, 2022

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The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.

Featured Abstract

Associations of amyloid and neurodegeneration plasma biomarkers with comorbidities.

COVID-19 vaccines have been associated with a rare life-threatening thrombotic and thrombocytopenic adverse reaction, vaccine-induced immune thrombotic thrombocytopenia (VITT) characterized by high levels of platelet-activating anti-platelet factor 4 (PF4) antibodies. In this study, we evaluated the pathogenesis and clonality of VITT antibodies from five patients with VITT secondary to ChAdOx1 nCoV-19 (n=1) and Ad26.COV2.S (n=4) vaccination.

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Published to PubMed This Week

• Periprocedural outcomes associated with use of a left atrial appendage occlusion device in China.
  JAMA network open
• Kidney histopathology in ANCA-associated vasculitides treated with plasma exchange.
  Journal of the American Society of Nephrology
• Identification of two genetic loci associated with leukopenia after chemotherapy in breast cancer patients.
  Clinical Cancer Research
• Sclerosing extramedullary hematopoietic tumor in chronic myeloproliferative neoplasms.
  Blood
• Spurious CD34 expression in B-cell lymphoma due to nonspecific binding to PerCP-Cy5.5 fluorochrome conjugates: A rare phenomenon and a diagnostic pitfall.
  Cytometry. Part B, Clinical Cytometry
• Analytic and clinical performance of major commercial severe acute respiratory syndrome Coronavirus 2 molecular assays in the United States.
  Clinics in laboratory medicine
• Accuracy of a rapid multiplex polymerase chain reaction plus a chromogenic phenotypic test algorithm for detection of extended-spectrum β-lactamase and carbapenemase-producing gram-negative bacilli in positive blood culture bottles.
  Clinical infectious diseases
• Uric acid expression in carotid atherosclerotic plaque and serum uric acid are associated with cerebrovascular events.
  Hypertension
• Do patients want to be involved in their carpal tunnel surgery decisions? A multicenter study.
  The Journal of hand surgery
• Pharmacokinetic assessment of staphylococcal phage K following parenteral and intra-articular administration in rabbits.
  Frontiers in Pharmacology

Meghann Southwick

Meghann Southwick is a marketing specialist for Mayo Clinic Laboratories. She has worked at Mayo Clinic since 2021.