Mayo Clinic Laboratory and Pathology Research Roundup: Aug. 27

By Kelley Luedke • August 27, 2018

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The Research Roundup provides an overview of the past week’s research from Mayo Medical Laboratories consultants, including featured abstracts and complete list of published studies and reviews.

Featured Abstract

A Mechanism for Preventing Asymmetric Histone Segregation onto Replicating DNA Strands

How parental histone (H3-H4)2 tetramers, the primary carriers of epigenetic modifications, are transferred onto leading and lagging strands of DNA replication forks for epigenetic inheritance remains elusive. Mayo Clinic researchers show that parental (H3-H4)2 tetramers are assembled into nucleosomes onto both leading and lagging strands, with a slight preference for lagging strands. The lagging strand preference increases markedly in cells lacking Dpb3 and Dpb4, two subunits of the leading strand DNA polymerase, Pol ε, due to the impairment of parental (H3-H4)2 transfer to leading strands. Dpb3-Dpb4 binds H3-H4 in vitro and participates in the inheritance of heterochromatin. These results indicate that different proteins facilitate the transfer of parental (H3-H4)2 onto leading vs lagging strands, and that Dbp3-Dpb4 plays a significant role in this poorly understood process. The study was published in Science.

Published to PubMed This Week

• • • • • Axoneme Polyglutamylation Regulated by Joubert Syndrome Protein ARL13B Controls Ciliary Targeting of Signaling Molecules
          Nature Communications
        • Teaching NeuroImages: Not a typical spinal mass
          Neurology
        • Accumulation of Gadolinium in Human Cerebrospinal Fluid after Gadobutrol-enhanced MR Imaging: A Prospective Observational Cohort Study
          Radiology
        • Renal Disorders in Pregnancy: Core Curriculum 2019
          American Journal of Kidney Diseases
        • Molecular and Ultrastructural Features of Diffuse Intrapulmonary Malignant Mesothelioma
          American Journal of Surgical Pathology
        • Neuropilin-1 Maintains Dimethylarginine Dimethylaminohydrolase 1 Expression in Endothelial Cells, and Contributes to Protection from Angiotensin II-Induced Hypertension
          FASEB J
        • Predictors of Symptomatic Hyperviscosity in Waldenström Macroglobulinemia
          American Journal of Hematology
        • Autoimmune Cytopenias in Patients with Chronic Lymphocytic Leukaemia Treated with Ibrutinib in Routine Clinical Practice at an Academic Medical Center
          British Journal of Haematology
        • Standardized Classification and Reporting of Glomerulonephritis
          Nephrology Dialysis Transplantation
          
        • Evaluation of a Novel Microarray Immunoblot Assay for Detection of IgM- and IgG-class Antibodies to Borrelia burgdorferi
          Journal of Clinical Microbiology
          
        • Frozen Section for Detection of Lymph Nodes After Cervical Injection with Indocyanine Green (ICG) for Sentinel Lymph Node Technique in Endometrial Cancer Staging
          Annals of Surgical Oncology
          
        • Core-Binding Factor Acute Myeloid Leukemia with t(8;21): Risk Factors and a Novel Scoring System (I-CBFit)
          Cancer Medicine
          
        • Pediatric Radiology Mission Work: Opportunities, Challenges and Outcomes
          Pediatric Radiology
        • Personalized Treatment of Malignant Mesothelioma-Dream or Reality?
          Journal of Thoracic Disease
          
        • Distinguishing IgG4-Related Ophthalmic Disease From Graves Orbitopathy
          Ophthalmic Plastic & Reconstructive Surgery

Kelley Luedke

Kelley Luedke is a Marketing Channel Manager at Mayo Clinic Laboratories. She is the principle editor and writer of Insights and leads social media and direct marketing strategy. Kelley has worked at Mayo Clinic since 2013. Outside of work, you can find Kelley running, traveling, playing with her kitty, and exploring new foods.