Mayo Clinic Laboratory and Pathology Research Roundup: Nov. 12

By Kelley Luedke • November 12, 2018

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The Research Roundup provides an overview of the past week’s research from Mayo Medical Laboratories consultants, including featured abstracts and complete list of published studies and reviews.

Featured Abstract

A Mechanism for Preventing Asymmetric Histone Segregation onto Replicating DNA Strands

How parental histone (H3-H4)2 tetramers, the primary carriers of epigenetic modifications, are transferred onto leading and lagging strands of DNA replication forks for epigenetic inheritance remains elusive. Mayo Clinic researchers show that parental (H3-H4)2 tetramers are assembled into nucleosomes onto both leading and lagging strands, with a slight preference for lagging strands. The lagging-strand preference increases markedly in budding yeast cells lacking Dpb3 and Dpb4, two subunits of the leading strand DNA polymerase, Pol ε, owing to the impairment of parental (H3-H4)2 transfer to leading strands. Dpb3-Dpb4 binds H3-H4 in vitro and participates in the inheritance of heterochromatin. These results indicate that different proteins facilitate the transfer of parental (H3-H4)2 onto leading versus lagging strands and that Dbp3-Dpb4 plays an important role in this poorly understood process. The study was published in Science.

Published to PubMed This Week

• • • • • Effect of Inorganic Nitrite vs. Placebo on Exercise Capacity Among Patients With Heart Failure With Preserved Ejection Fraction: The INDIE-HFpEF Randomized Clinical Trial
          JAMA
        • The Return of Actionable Variants Empirical (RAVE) Study, a Mayo Clinic Genomic Medicine Implementation Study: Design and Initial Results
          Mayo Clinic Proceedings
        • Classic Hodgkin Lymphoma
          Mayo Clinic Proceedings
          
        • Novel BRAF Alteration in Desmoplastic Infantile Ganglioglioma with Response to Targeted Therapy
          Acta Neuropathologica Communications
        • A Risk-Stratified Approach to Neoadjuvant Chemotherapy in Muscle-Invasive Bladder Cancer: Implications for Patients Classified with Low-Risk Disease
          World Journal of Urology
        • Adamantinoma of Bone: Long-Term Follow-up of 46 Consecutive Patients
          Journal of Surgical Oncology
        • Diagnostic Laboratory Standardization and Validation of Platelet Transmission Electron Microscopy
          Platelets
        • Conducting Maximal and Submaximal Endurance Exercise Testing to Measure Physiological and Biological Responses to Acute Exercise in Humans
          Journal of Visualized Experiments

Kelley Luedke

Kelley Luedke is a Marketing Channel Manager at Mayo Clinic Laboratories. She is the principle editor and writer of Insights and leads social media and direct marketing strategy. Kelley has worked at Mayo Clinic since 2013. Outside of work, you can find Kelley running, traveling, playing with her kitty, and exploring new foods.