An 82-year-old male with well-controlled HIV and macrocytic anemia undergoes a bone marrow biopsy. The morphologic findings are subtle, including few slightly atypical eosinophils on peripheral blood, mild granulocytic hyperplasia, a single paratrabecular cluster of eosinophils, and few spindled mast cells. There is no overall marrow or blood eosinophilia. Karyotype detects a t(4;22)(q12;q11.2) clonal abnormality involving PDGFRA (4q12) by break-apart FISH. Mate pair sequencing demonstrates a fusion between the PDGFRA and SPECC1L genes.
This quiz is no longer available.Daniel (Dan) P. Larson, M.D. Resident, Anatomic and Clinical Pathology Mayo Clinic |
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Pedro Horna, M.D. Senior Associate Consultant, Hematopathology Mayo Clinic Associate Professor of Laboratory Medicine and Pathology Mayo Clinic College of Medicine |