Research Roundup

This week's research roundup feature: Bicuspid aortic valve (BAV) is the most common congenital heart anomaly. Lifetime morbidity and whether long-term survival varies according to BAV patient-sub-groups are unknown. This study aimed to assess lifetime morbidity and long-term survival in BAV patients in the community.

By Sarah Jarvis • November 21, 2023

This week's research roundup feature: Microaggressions between members of a team occur often in medicine, even despite good intentions. Such situations call for difficult conversations that restore inclusivity, diversity, and a healthy work culture. These conversations are often hard because of the unique background, experiences, and biases of each person. In medicine, skillful navigation of these interactions is paramount as it influences patient care and the workplace culture.

By Sarah Jarvis • November 14, 2023

This week's research roundup feature: Cytomegalovirus (CMV) is a significant cause of morbidity and mortality among immunocompromised hosts, including transplant recipients. Antiviral prophylaxis or treatment is used to reduce the incidence of CMV disease in this patient population; however, there is concern about increasing antiviral resistance.

By Sarah Jarvis • November 7, 2023

This week's research roundup feature: It is widely held that heart failure (HF) does not cause exertional hypoxaemia, based upon studies in HF with reduced ejection fraction, but this may not apply to patients with HF and preserved ejection fraction (HFpEF). Here, we characterize the prevalence, pathophysiology, and clinical implications of exertional arterial hypoxaemia in HFpEF.

By Sarah Jarvis • October 31, 2023

This week's research roundup feature: Renal fibrosis is now recognized as a main determinant of renal pathology to include chronic kidney disease. Deposition of pathological matrix in the walls of glomerular capillaries, the interstitial space, and around arterioles predicts and contributes to the functional demise of the nephron and its surrounding vasculature.

By Sarah Jarvis • October 24, 2023

This week's research roundup feature: Given the prevalence of dementia and the development of pathology-specific disease modifying therapies, high-value biomarker strategies to inform medical decision making are critical. In-vivo tau positron emission tomography (PET) is an ideal target as a biomarker for Alzheimer's disease diagnosis and treatment outcome measure.

By Sarah Jarvis • October 17, 2023

This week's research roundup feature: Membranous nephropathy (MN) is a pattern of injury caused by autoantibodies binding to specific target antigens, with accumulation of immune complexes along the subepithelial region of glomerular basement membranes.

By Sarah Jarvis • October 10, 2023

This week's research roundup feature: Gene fusions involving tumor protein p63 gene (TP63) occur in multiple T and B cell lymphomas and portend a dismal prognosis for patients. The function and mechanisms of TP63 fusions remain unclear, and there is no target therapy for patients with lymphoma harboring TP63 fusions. Here, we show that TP63 fusions act as bona fide oncogenes and are essential for fusion-positive lymphomas.

By Sarah Jarvis • October 3, 2023

This week's research roundup feature: Semaglutide in HFpEF across obesity class and by body weight reduction.

By Sarah Jarvis • September 26, 2023

This week's research roundup feature: There is a need to develop safe and effective pharmacologic options for the treatment of celiac disease (CeD); however, consensus on the appropriate design and configuration of randomized controlled trials (RCTs) in this population is lacking.

By Sarah Jarvis • September 19, 2023

This week's research roundup feature: Activated mast cells in periprosthetic joint infection-associated tissue.

By Samantha Rossi • September 12, 2023

This week's research roundup feature: 16S rRNA gene PCR/Sequencing of heart valves for diagnosis of infective endocarditis in routine clinical practice.

By Samantha Rossi • September 5, 2023

This week's research roundup feature: Association of plasma biomarkers of Alzheimer Disease with cognition and medical comorbidities in a biracial cohort.

By Samantha Rossi • August 22, 2023