Streamlined evaluation for an easier experience
Helicobacter pylori, or H. pylori, is one of the world’s most common chronic bacterial infections. Estimated to impact 4.4 billion individuals globally, H. pylori affects 35% to 89% of children, depending on the geographic region in which they live.1, 2 Because H. pylori is the main cause of peptic ulcer disease and a major risk factor for gastric cancer, treatment is essential to prevent life-threatening medical conditions. Timely, accurate diagnosis is critical for improving outcomes and preventing further harm.
The rising prevalence of antimicrobial resistance presents a clinical challenge when deciding who to test and how to select the best treatment for H. pylori infection. Mayo Clinic Laboratories’ H. pylori assay provides clinicians a streamlined solution to the challenge of diagnosing and treating the infection in children by evaluating for both the bacteria and antimicrobial resistance through one noninvasive test.
Simplified collection, noninvasive analysis
While identification of antimicrobial susceptibility to H. pylori was until recently only possible through an invasive endoscopic procedure, Mayo Clinic Laboratories’ noninvasive option is especially suited for children. Our assay is the only clinically available test of its kind and uses a single stool specimen to predict clarithromycin resistance.
This polymerase chain reaction assay interrogates the three 23S ribosomal RNA gene mutations most often associated with clarithromycin resistance. This enables results that can aid clinicians in determining the best therapy for eradicating H. pylori in each child — an approach that helps families get the right treatment, right away.
In this Hot Topic, Robin Patel, M.D., discusses Mayo Clinic Laboratories’ new PCR assay for detection of Helicobacter pylori detection and determination of clarithromycin resistance directly from stool.
When should I order H. pylori testing?
Mayo Clinic Laboratories’ H. pylori diagnostic algorithm can help determine who is a good candidate for these tests.