Pathways – Clinical Pathology

This "Pathways" program provides Anatomic and Clinical Pathology cases that include a history, potential answers, rationale, and relevant references. Cases for January include the following sub-specialties: bone and soft tissue, cellular therapy, laboratory genetics and genomics, and pulmonary

Chimeric antigen receptor T cells (CAR T cells) represent an exciting new area of cellular therapy. Manufacturing autologous CAR T cells involves virally transducing a[...]

A 19 year old female with a complex phenotype suggestive of a mitochondrial disorder had mitochondrial DNA sequencing performed three times at an outside institution,[...]

This "Pathways" program provides Anatomic and Clinical Pathology cases that include a history, potential answers, rationale, and relevant references. Cases for December include the following sub-specialties: Biochemical Genetics, Bone and Soft Tissue, Dermatopathology, and Genitourinary.

64 year old female with an outside diagnosis of porphyria cutanea tarda (PCT), with a new onset of abdominal pain. She had a complex constellation[...]

This "Pathways" program provides Anatomic and Clinical Pathology cases that include a history, potential answers, rationale, and relevant references. Cases for November include the following sub-specialties: Cytogenetics, Genetics, Gynecological, and Molecular Genetics.

1-day-old female born with omphalocel, macroglossia, and enlarged kidneys. Julie Li, B.Med., Ph.D.Fellow, Molecular Genetic PathologyMayo Clinic Matthew Ferber, Ph.D.Consultant, Laboratory Genetics and GenomicsMayo ClinicAssociate[...]

A 30-year-old woman suffers a miscarriage, and the product of conception is sent for cytogenetic testing to rule out cytogenetic abnormalities. A chromosomal microarray performed[...]

α-globin gene analysis testing was performed on a 30-year-old man with unknown clinical history. Gene dosage was assessed using multiplex ligation-dependent probe amplification (MLPA). Multiplex[...]

This "Pathways" program provides Anatomic and Clinical Pathology cases that include a history, potential answers, rationale, and relevant references. Cases for October include the following sub-specialties: Cytogenetics, Endocrine, Gastrointestinal, Neuropathology, and Transfusion Medicine.

A 61-year-old male developed flu-like symptoms with persistent cough. He had an episode of hemoptysis and presented for evaluation in the clinic. A chest x-ray[...]

A 32-year-old G1P0 woman has an initial type and screen at her first prenatal appointment. She is B positive and her antibody screen is negative.[...]

Mayo Clinic laboratory experts share five case studies in this month’s “PathWays” post and are challenging you to test your laboratory genetics & genomics, bone & soft tissue, renal, infectious disease, and gastroenterology pathology knowledge. Review the cases, take the quizzes, and learn how the correct diagnoses were made.