Pathways – Clinical Pathology

A 55-year-old female with history of eating disorder and high output ileostomy presented with electrolyte abnormalities, dehydration, chronic kidney failure, and severe QT prolongation. Initial[...]

A 61 year old man with a 1.5 year history of eosinophilia (absolute eosinophil count up to 32x109) undergoes a third bone marrow biopsy. Prior[...]

Mayo Clinic laboratory experts share three case studies in this month’s “PathWays” post and are challenging you to test your anatomic and clinical pathology, laboratory genetics and genomics, and pathology and cytology knowledge. Review the cases, take the quizzes, and learn how the correct diagnoses were made.

A 60-year-old man presented with a slow-growing non-painful 4.5 cm mass of the left parotid gland and underwent surgical excision. Below is an hematoxylin and[...]

A 52-year-old male underwent whole-exome sequencing (WES) for amyotrophic lateral sclerosis (ALS). While no germline alterations relevant to his ALS were detected, multiple de novo[...]

Mayo Clinic laboratory experts share three case studies in this month’s “PathWays” post and are challenging you to test your Clinical Pathology, Molecular Diagnostic, Hematopathology, and Dermatology pathology knowledge. Review the cases, take the quizzes, and learn how the correct diagnoses were made.

A 59-year-old man with a history of HIV presented with a 6 cm mass involving the left palatine tonsil. Biopsy of the mass showed the[...]

A child was born with features consistent with Down syndrome. Karyotype results were 46,XY,der(21;21)(q10;q10),+21, supporting the clinical diagnosis. Parental chromosomal analysis was completed as a[...]

A 13-month-old female infant was referred for delayed milestones, atrial septal defect, low-set ears, mild hypertelorism, and iridal coloboma. Chromosome analysis was performed, which showed[...]

Mayo Clinic laboratory experts share four case studies in this month’s “PathWays” post and are challenging you to test your blood education, neuropathology, breast pathology, and clinical pathology knowledge. Review the cases, take the quizzes, and learn how the correct diagnoses were made.

A 52-year-old female presented to the emergency department with chest discomfort. Cardiac troponin I (TnI), measured using a goat antibody-based sandwich immunoassay (ADVIA Centaur, Siemens[...]

Mayo Clinic laboratory experts share four case studies in this month’s PathWays post and are challenging you to test your anatomic pathology, infectious disease pathology, laboratory genetics, and gastrointestinal pathology knowledge. Review the cases, take the quizzes, and learn how the correct diagnoses were made.

A 25-year-old female presented with extreme malnourishment (BMI=9). Her nutrition has been suffering due to severe gastroparesis along with cyclic vomiting and food intolerance. Her[...]