Pathways – Clinical Pathology

Mayo Clinic laboratory experts share four case studies in this month’s PathWays post and are challenging you to test your blood, clinical pathology, hematopathology, and anatomic pathology knowledge. Review the cases, take the quizzes, and learn how the correct diagnoses were made.

A 57-year-old female presented with easy bruising, hirsutism, and weight loss. Morning serum cortisol was 54.1 mcg/dL (reference interval (RI): 7-25 mcg/dL) with an adrenocorticotropic[...]

Here, we report a case of a 56-year-old African-American female with a reported history of “alpha thal trait” found to have severe reticulocytopenic microcytic anemia[...]

Mayo Clinic laboratory experts share four case studies in this month's PathWays post and are challenging you to test your gastrointestinal, molecular diagnostics, and hematopathology knowledge. Review the cases, take the quizzes, and learn how the correct diagnoses were made.

A 49-year-old male with prior history of severe progressive peripheral neuropathies in his extremities was diagnosed at an outside institution with chronic inflammatory demyelinating polyneuropathy. Treatments[...]

A 33-year-old man presented with a history of infertility. A blood sample was submitted to the laboratory for molecular analysis of Y chromosome microdeletions. Analysis[...]

A 32-year-old female presented to OB/GYN at 18 weeks gestation. Mutliple ultrasound anomalies were detected, including postaxial polydactyly, choroid plexus cysts, and omphalocele. Non-invasive prenatal[...]

Mayo Clinic laboratory experts share four case studies in this month's PathWays post and are challenging you to test your anatomic pathology and laboratory genetics knowledge. Review the cases, take the quizzes, and learn how the correct diagnosis was made. Good luck.

A 68-year-old woman underwent endometrial biopsy for post-menopausal bleeding, which showed endometrial adenocarcinoma, endometrioid type. The screening test for Lynch syndrome by IHC (dMMR-IHC) and[...]

This month’s PathWays Case Studies test your anatomic pathology, laboratory genetics, hematopathology, and clinical core laboratory knowledge. View each case and see if you can make the correct diagnosis.

​A six-year-old boy presented with fever and bone pain. He was found to have thrombocytopenia, anemia, and splenomegaly. MRI showed bone marrow abnormality. A hematologic malignancy[...]

​This is a 19-year-old female with microcytic anemia. A colonoscopy revealed a polyp in the descending colon. After the procedure, she developed fever, and a[...]

​A 36-year-old male presented to the clinic for routine warfarin monitoring. Blood was drawn for prothrombin time testing. In the lab, a medical technologist noted[...]