This week’s Research Roundup highlights the development and validation of a prostate cancer genomic signature that predicts early androgen deprivation therapy (ADT) treatment response following radical prostatectomy.

Melanoma, the skin cancer often associated with sun exposure, is on the rise and has no reliable cure. Mayo Clinic is at the forefront of these efforts. The Center for Individualized Medicine is unraveling the complex behavior of melanoma at the molecular level—to allow for treatment that better targets an individual’s disease.

This week’s Research Roundup highlights potential genetic modifiers of disease risk and age at onset in patients with frontotemporal lobar degeneration and GRN mutations.

This week’s Research Roundup highlights how fasting blood-glucose levels provide estimate of duration and progression of pancreatic cancer before diagnosis.

This week’s Research Roundup highlights a model for predicting breast cancer risk in women with atypical hyperplasia.

This week’s Research Roundup highlights different mutational rates and mechanisms in human cells at pregastrulation and neurogenesis.

This week’s Research Roundup highlights the clinical and pathological phenotype of genetic causes of focal segmental glomerulosclerosis in adults.

This week’s Research Roundup highlights genetic evidence for early peritoneal spreading in pelvic high-grade serous cancer.

This week’s Research Roundup highlights patterns of homozygosity in patients with uniparental disomy with detection rate and suggested reporting thresholds for SNP microarrays.

This week’s Research Roundup highlights the development of a microscopic colitis disease activity index.

This week’s Research Roundup highlights the analysis of cell-free DNA to assess risk of tumoremia following endoscopic ultrasound fine-needle aspiration of pancreatic adenocarcinomas.

This week’s Research Roundup highlights cardiovascular concerns in BRCA1 and BRCA2 mutation carriers.

This week’s Research Roundup highlights high grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements with diffuse large B-cell lymphoma morphology.