Mayo Clinic Laboratories > BioPharma Diagnostics > Testing > Neurology

Neurology

FULL SPECTRUM OF NEUROLOGICAL DISEASE TESTING

A collaboration with BioPharma Diagnostics includes access to the neurologic disease testing capabilities of Mayo Clinic Laboratories. Our highly specialized neurology testing menu features more than 400 neurologist-backed assays to evaluate the simplest to most complex cases. From analyses for Alzheimer’s disease and dementia to targeted antibody detection for autoimmune neurology conditions, our robust testing library provides partners with results that move solutions through the development pipeline.

With 19 subspecialty labs that perform testing, we are at the forefront of research that integrates novel biomarker discoveries into our evaluations. Our clinical experience gives us the expertise to develop tests that deliver actionable answers.

To learn more about our testing, view our biopharma-specific test catalog and full test catalog.

Test menu

Biopharma only testing Biopharma only testing
Biopharma only testing

Our BioPharma Diagnostics-specific neurology testing is designed to provide answers for your patients.

Full suite of neurology testing Full suite of neurology testing
Full suite of neurology testing

Mayo Clinic Laboratories is leading an evolution in neurology testing. Propelled by ongoing discoveries of clinically relevant biomarkers, our laboratory scientists integrate research findings into test development and implementation. Collaboration between our labs and the clinical practice at Mayo Clinic supports development of clinically validated testing that delivers actionable answers for patients.

Dementia Dementia
Dementia

Offering the industry’s most sophisticated suite of testing available, including biomarker evaluations, autoimmune panels, testing for rapidly progressive cases, and an innovative combination assay, Mayo Clinic Laboratories is a one-stop laboratory solution for dementia and Alzheimer’s disease testing.

Demyelinating disease Demyelinating disease
Demyelinating disease

Driven by ongoing research into the presence of antibody biomarkers in patients with immune-mediated demyelinating neuropathy, Mayo Clinic Laboratories has developed several unique, highly accurate assays that use pioneering methods to identify specific biomarkers associated with the harmful immune response. Order these tests when nerve conduction studies show prolonged distal latency or marked slowing of conduction velocities.

Epilepsy Epilepsy
Epilepsy

Proper identification of immune-mediated epilepsy is vital to directing appropriate treatment. Our autoimmune epilepsy evaluation detects for more than a dozen antibody biomarkers related to autoimmune causes.

Mitochondrial disease Mitochondrial disease
Mitochondrial disease

We offer four molecular test options that can complement radiological and histological evaluations to confirm a mitochondrial diagnosis and identify a specific mitochondrial syndrome. Rather than a series of targeted panels or single-gene analysis, we recommend sequencing the entire mitochondrial genome and/or performing a comprehensive nuclear gene panel.

Movement disorders Movement disorders
Movement disorders

Our comprehensive autoimmune movement disorders panel is continuously updated to include newly discovered antibody biomarkers and uses advanced testing approaches to detect actionable antibodies. Data-backed and developed by our autoimmune neurology experts, our evaluations include detection of several antibody biomarkers available only at Mayo Clinic Laboratories.

Neuromuscular disorders Neuromuscular disorders
Neuromuscular disorders

Our distinctive approach to testing for genetic neuromuscular disorders uses phenotypic information to streamline diagnosis. Phenotype-specific panels enable targeted testing, improving diagnosis and minimizing uncertain results.

Peripheral neuropathy Peripheral neuropathy
Peripheral neuropathy

Our hereditary peripheral neuropathy test menu includes both comprehensive and targeted NGS panels to assist in identifying genetic causes across the spectrum of peripheral neuropathies.

Sleep disorders Sleep disorders
Sleep disorders

Our testing to assess for narcolepsy evaluates for low concentrations of orexin-A/hypocretin-1 in cerebrospinal fluid. Sensitive and specific, this evaluation provides results that can guide appropriate treatment for patients.

Neurology testing overview

The rapid expansion of neurology testing has resulted in the discovery of increasing numbers of clinically relevant biomarkers. Mayo Clinic Laboratories collaborates closely with the clinical practice to develop and offer advanced testing — much of which is unavailable anywhere else — to address the most difficult questions.

Our laboratories are led by board-certified clinical neurologists and clinical chemists who have extensive experience using testing to guide patient care. These experts are available for consultations on test selection and results interpretation. Our physicians are committed to research and discovery to pave the way for the future of neurology testing.

Comprehensive disease testing

A collaboration with BioPharma Diagnostics includes access to the neurologic disease testing capabilities of Mayo Clinic Laboratories, including: 

  • Alzheimer's disease
  • Demyelinating disease
  • Epilepsy
  • Mitochondrial disease
  • Movement disorders
  • Neuromuscular disorders
  • Peripheral neuropathy
  • Sleep disorders
News and updates

The latest

Diagnostic ecosystem boosts access to timely Alzheimer’s disease testing

Mayo Clinic Laboratories has developed a cutting-edge suite of Alzheimer's disease testing. The newest assays use blood samples, avoiding the need for lumbar punctures to obtain cerebrospinal fluid. The testing suite exemplifies Mayo Clinic Laboratories' innovative business approach. As a platform company, Mayo Clinic is creating a diagnostics ecosystem to meet a wide range of testing needs and help physicians order the right tests for their patients.

Learn more
Reversing a dire disorder: Lorinda McKinley

Advanced testing at Mayo Clinic Laboratories that confirmed a diagnosis of myasthenia gravis put Lorinda McKinley on the road to renewed health after she nearly lost it all to the rare autoimmune disease.

Neurofascin 155 IgG4 Antibody Test [Test in Focus]

John Mills, Ph.D., explains Mayo Clinic Laboratories' new neurofascin 155 (NF155) IgG4 antibody test, which is the first commercially available test in the U.S. to use flow cytometry to detect for NF155 antibodies and confirm diagnosis of CIDP.

Mitochondrial Disease [Test in Focus]

Linda Hasadsri, M.D., Ph.D., explains how Mayo Clinic Laboratories’ inclusive approach to mitochondrial disease testing expedites diagnosis. Using innovative methodologies like custom reagents and droplet digital PCR enables precision insights on prognosis and treatment options.

Shining light on one family’s struggle: Barbara, Deborah, Pamela, and Rylie

Before testing at Mayo Clinic Laboratories, Barbara Domaille, Deborah Neville, Pamela Neville, and Rylie Ronnenberg thought there could be a genetic connection to the hip problems they shared. After the testing, they knew for sure.

MAG Antibody Testing [Test in Focus]

John Mills, Ph.D., explains Mayo Clinic Laboratories’ approach to MAG antibody testing. The ELISA-based assay uses higher reference ranges and human MAG antigen to detect MAG antibodies, which are associated with a rare, hard-to-treat condition known as DADS neuropathy.

Kelch-like protein 11 autoantibodies: A novel biomarker of testicular cancer associated neurological autoimmunity

This “Specialty Testing” webinar will discuss the collaborative effort which led to the discovery of Kelch like protein 11 (KLHL11) IgG as a specific biomarker of neurological autoimmunity associated testicular germ cell tumor.

Kelch-11 Autoantibody Test [Test in Focus]

Divyanshu (Div) Dubey, M.B.B.S., explains how Mayo Clinic Labs’ new Kelch-11 antibody test — the first in the world — can confirm diagnosis, guide treatment, and improve outcomes in patients affected by testicular cancer-associated paraneoplastic encephalitis.

Mayo Clinic Laboratories offers first test to detect recently discovered autoimmune disease associated with testicular cancer

Mayo Clinic Laboratories has launched a first-in-the-U.S. autoimmune test of the Kelchlike protein 11 antibody, or KLHL11, which is used to detect autoimmune disease associated with testicular cancer.

Week in Review: June 11

Top highlights include: which insurance companies cover the new Alzheimer's drug, advice on how to talk to someone who is hesitant to get the COVID-19 vaccine, employers requiring you to be vaccinated, FDA approval Alzheimer drug, MN COVID-19 numbers heading in the right direction, having "brain frog" and blaming the pandemic.

Neuroimmunology: Updates and antibody test utilization

In this month’s “Hot Topic,” Andrew McKeon, M.B., B.Ch., M.D., reviews the use of neurological phenotype-based evaluations, the move away from the paraneoplastic evaluation, and upcoming changes to test profiles.

Autoimmune Profile Updates [Test in Focus]

Andrew McKeon, M.B., B.Ch., M.D., discusses updates that are being made to Mayo Clinic Laboratories' autoimmune profile that will remove some antibodies from those profiles. He describes the rationale behind the updates, reviews which antibodies are involved, and explains how the changes will streamline testing and enhance test interpretation.

Autoimmune profile updates

Based on studies that have shown certain antibodies may not be as clinically relevant to autoimmune testing as previously thought, Mayo Clinic Laboratories is updating a number of its autoimmune profiles by removing some antibodies from them.

View More
INTERESTED IN LEARNING MORE?

Fill out the form below and one of our specialists will be in touch.

Are you a patient? Click here.