Pathways – Clinical Pathology

This "Pathways" program provides Anatomic and Clinical Pathology cases that include a history, potential answers, rationale, and relevant references. Cases for February include the following sub-specialties: Anatomic Pathology, Cytopathology, Clinical Microbiology, Gastroenterology, Hematopathology, Infectious Disease, and Laboratory Genetics & Genomics

A 65-year-old man with history of treated anal intraepithelial neoplasia presents with new-onset diarrhea. A Papanicolaou-stained anal smear was performed for follow-up cancer screening. Nicholas[...]

A 43-year-old female presents with seizures following weeks of progressive lower extremity numbness. Imaging reveals a contrast-enhancing parasagittal brain mass without other systemic findings. She[...]

A 71 yr old female with a history of a central nervous system lymphoma, an allogenic stem cell transplant and graft versus host disease was[...]

This "Pathways" program provides Anatomic and Clinical Pathology cases that include a history, potential answers, rationale, and relevant references. Cases for January include the following sub-specialties: bone and soft tissue, cellular therapy, laboratory genetics and genomics, and pulmonary

Chimeric antigen receptor T cells (CAR T cells) represent an exciting new area of cellular therapy. Manufacturing autologous CAR T cells involves virally transducing a[...]

A 19 year old female with a complex phenotype suggestive of a mitochondrial disorder had mitochondrial DNA sequencing performed three times at an outside institution,[...]

This "Pathways" program provides Anatomic and Clinical Pathology cases that include a history, potential answers, rationale, and relevant references. Cases for December include the following sub-specialties: Biochemical Genetics, Bone and Soft Tissue, Dermatopathology, and Genitourinary.

64 year old female with an outside diagnosis of porphyria cutanea tarda (PCT), with a new onset of abdominal pain. She had a complex constellation[...]

This "Pathways" program provides Anatomic and Clinical Pathology cases that include a history, potential answers, rationale, and relevant references. Cases for November include the following sub-specialties: Cytogenetics, Genetics, Gynecological, and Molecular Genetics.

1-day-old female born with omphalocel, macroglossia, and enlarged kidneys. Julie Li, B.Med., Ph.D.Fellow, Molecular Genetic PathologyMayo Clinic Matthew Ferber, Ph.D.Consultant, Laboratory Genetics and GenomicsMayo ClinicAssociate[...]

A 30-year-old woman suffers a miscarriage, and the product of conception is sent for cytogenetic testing to rule out cytogenetic abnormalities. A chromosomal microarray performed[...]

α-globin gene analysis testing was performed on a 30-year-old man with unknown clinical history. Gene dosage was assessed using multiplex ligation-dependent probe amplification (MLPA). Multiplex[...]